Three months ago, I purchased a brand new Windows 7 computer - Intel Core i7-3770/ 8.0 GB. 

During three months period, I had ZERO problems/issues with my computer.

After receiving e-mails from Microsoft "What are you waiting for", I upgraded it to Windows 8.

Since then, I have had two refresh, and four days ago, a clean install of Windows 8, because NOTHING WORKED. No refresh, no reset, no MS-DOS, no restore point, no repairs, etc...

What to do when you get the following message on "the most stable", Windows 8, operating system?
"The drive where Windows is installed is locked. Unlock the drive and try again."

I got that message after the following:
I wanted to open a PDF file from my customer on OUTLOOK - a regular, every-hour procedure - and my computer froze. Nothing worked; therefore, only manually disconnecting my computer from the power source, I was able to shut it down.
After I restarted, I could not get passed the login screen - my computer used to enter the "blue background color and nothing else" mode. 
I decided to use USB Flash drive to repair Win8 but it failed. I wanted to refresh my Windows 8, but I got that message:
"The drive where Windows is installed is locked. Unlock the drive and try again."

Just 4 days ago, I did a "clean install" of Windows 8 OS.

What should I do besides another "clean install" of Windows 8?

"Windows Resource Protection could not start the repair service".

If I try to run CHKDSK, I get the following message:

"Errors detected in the uppercase file.

Windows has checked the file system and found problems.

...

Failed to transfer logged messages to the event log with status 50.

If I run CHKDSK/F, I get the following:

"Cannot lock current drive, Windows cannot run disk checking on this volume because it is write protected."

Why did I upgrade the most stable Windows 7 to Windows 8?

Hi,

To run CHKDSK, you have to launch it with elevated privileges (Run as Administrator...)

Hi,

To run CHKDSK, you have to launch it with elevated privileges (Run as Administrat

I can't use dvd. It says, your drive is locked. Please unlock the drive.

Also, I cannot see a dvd option when I open my BIOS.

An update about my frozen computer.

Last night, I entered my password and left my computer running overnight. This morning, I was able to log-in and get to my Desktop Screen.
As soon as I tried to open my MS Access database, my computer froze.
I can use "Windows Key + X" but cannot open anything - Task Manager, Command Prompt, File Explorer.

I've just clicked on "Windows Key" and got to METRO Interface. Right now, my computer really froze. No reaction to the keyboard anymore. My mouse is movable.
What should I do?
Please help.

@zmechys

Try the following:

1. Copy all the files from your downloaded ISO you've used to install Windows 8 to a USB stick.

2. Boot from that USB stick and press Shift+F10 when Windows 8 setup WinPE shell starts.

3. In the command prompt type:

x:\>chkdsk /f /v /r /b /offlinescanandfix c:

NOTE: Make sure c: is your boot drive with your OS by running

x:\>diskpart

DISKPART> list disk

DISKPART> select disk 0

DISKPART> list volume

DISKPART> exit

I would also check your PC for viruses by downloading a LiveCD with an antivirus, booting from it, and scanning your PC from this LiveCD. You could try Kaspersky Rescue Disk, or you can grab a free tool to check your system in-place, right from Windows 8, from here.

I just realized something that made me feel pretty stupid for not having thought of this sooner but, i tried booting from the manual boot menu selection screen and made sure to boot from notebook hard drive and right then it dawned on me lol, it also gave the USB hard drive option so i unplugged it and then rebooted normally. and my system booted perfectly fine. I realized that even though my usb harddrive is a slave disk, it was automatically booting from the usb drive before attempting the internal hard drive. so check your boot options.

Hope that helps.